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This week's show is made possible by a generous amount of existential anxiety, from the ego-destroying rock anthem "I Don't Matter At All" to an epic life manifesto from Amanda Palmer.

The week's best new album drops includes the genre-bending pop of Charli XCX, an ambitious concept record by The Lumineers, the euphoric songs of Emeli Sandé, new Chelsea Wolfe, Sampa The Great, more.

After four or five of his patients died from opioid overdoses in one month, Craig Smith, a family doctor in Bridgton, Maine, realized he couldn't wait for someone else to offer addiction treatment.

Escobedo had been leading Kimmel's house band since the show launched in 2003. The musician and the comedian were childhood friends in Las Vegas.

As more schools band together to commit to recruiting and graduating 50,000 more low-income students, four college presidents discuss what it will take to get there.

Chicago rapper Juice WRLD's Deathrace for Love,a beautiful new self-titled album from Patti Griffin and Helado Negro's This is How You Smileare just some of our picks for the week's best new albums.

Andy Gregory plays music from the Local 518

The case could have broad impact on how the First Amendment is applied in other trademark cases.

The Grammy Award-winning 12-piece, led by husband and wife Derek Trucks and Susan Tedeschi, is releasing its new album, Signs, this February.

Join Andy Gregory tonight at 6pm for the Local 518 ‪‎Show‬. There's music by Ryan Clark, Acid Reins, Band of Ghosts, Red Haired Strangers, Benjamin…